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Reduced genioglossus muscle activity caused by fluid overload in anesthetized rats

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Although the precise cause of obstructive sleep apnea (OSA) remains unknown, various anatomical or structural factors are thought to influence upper airway patency. Recent clinical studies show that OSA is… Click to show full abstract

Although the precise cause of obstructive sleep apnea (OSA) remains unknown, various anatomical or structural factors are thought to influence upper airway patency. Recent clinical studies show that OSA is frequently observed among patients with fluid‐retaining states, such as heart/renal failure and postsurgery. It is important to note that a cause–effect relationship is not yet established, and our understanding of the effects of fluid overload is limited. The goal of this study was to investigate an animal model that can characterize the physiological changes that occur in response to fluid overload.

Keywords: caused fluid; fluid overload; activity caused; reduced genioglossus; muscle activity; genioglossus muscle

Journal Title: Physiological Reports
Year Published: 2020

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