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Current understanding of ventricular action potential adaptation to physiological stress is generally based on protocols using non‐physiological rates and conditions isolating rate effects from escalating adrenergic stimulation. To permit refined… Click to show full abstract
Current understanding of ventricular action potential adaptation to physiological stress is generally based on protocols using non‐physiological rates and conditions isolating rate effects from escalating adrenergic stimulation. To permit refined understanding, ventricular action potentials were assessed across physiological pacing frequencies in the presence and absence of adrenergic stimuli. Isolated and combined effects were analyzed to assess their ability to replicate in‐vivo responses.
Journal Title: Physiological Reports
Year Published: 2022
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