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Abstract Several pyridopyrimidine derivatives have been synthesized through different synthetic processes. The different physicochemical factors for their synthesis were also discussed. A comparison between the conventional and microwave-assisted synthesis was… Click to show full abstract
Abstract Several pyridopyrimidine derivatives have been synthesized through different synthetic processes. The different physicochemical factors for their synthesis were also discussed. A comparison between the conventional and microwave-assisted synthesis was conducted by comparing total time of reaction and its yield percentage. Most of the produced uracils were established for their anti-inflammatory, analgesic, and antioxidant activities. Compounds 1 and 3 were demonstrated as the best results against DNA damage, whereas compounds 2a and 2b exhibited an effective anti-inflammatory activity. Moreover, the Lipinski rule parameters were calculated for the synthesized compounds. The results indicated that compounds 1, 2a and 5 have good potential for subsequent development bioactivity.
Journal Title: Green Processing and Synthesis
Year Published: 2017
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