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Recent progress in asymmetric synthesis of aminophosphonic acids mediated by chiral sulfinyl auxiliary

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Abstract This account outlines the recent results on our strategy of the diastereoselective asymmetric synthesis of aminophosphonic acids (APs) using enantiomeric sulfinimines as chirality inducing reagents. Three important topics are… Click to show full abstract

Abstract This account outlines the recent results on our strategy of the diastereoselective asymmetric synthesis of aminophosphonic acids (APs) using enantiomeric sulfinimines as chirality inducing reagents. Three important topics are discussed: (a) application of a double asymmetric induction in the synthesis of enantiomerically pure APs; (b) development of a general approach to the synthesis of γ-aminophosphonic acids (γ-APs) and (c) the use enantiomeric N-(p-tolylsulfinyl)cinnamaldimines in the synthesis of diverse α- and β-aminophosphonic acids (AP3, AP4) including the first synthesis of (R)-phosphoemeriamine.

Keywords: synthesis aminophosphonic; aminophosphonic acids; asymmetric synthesis; recent progress; progress asymmetric; synthesis

Journal Title: Pure and Applied Chemistry
Year Published: 2017

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