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Three recent publications in this journal have reported that the differences in IGF-1 normative data significantly impact the classification of patients with growth hormone (GH)- excess and deficiency disorders in… Click to show full abstract
Three recent publications in this journal have reported that the differences in IGF-1 normative data significantly impact the classification of patients with growth hormone (GH)- excess and deficiency disorders in such a way that clinical performance is severely flawed. This concerns not only pediatric but also adult patients. With this letter, we aim to address additional issues, not previously addressed, which add to the complexity of the interpretation of IGF-1 results. Specifically, the relation between analytical performance of IGF-1 assays and acceptable clinical performance is discussed.
Journal Title: European journal of endocrinology
Year Published: 2019
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