LAUSR

In their back-to-back published articles "Integrated Genomic Analysis of Hürthle Cell Cancer Reveals Oncogenic Drivers, Recurrent Mitochondrial Mutations, and Unique Chromosomal Landscapes" and "Widespread Chromosomal Losses and Mitochondrial DNA Alterations as Genetic Drivers in Hürthle Cell Carcinoma" Ganly and co-workers (Ganly, et al. 2018) and Gopal and co-workers (Gopal, et al. 2018), respectively, defined alterations in oncogenic drivers and mitochondrial DNA mutations complex I (mtDNA), including the widespread whole-chromosome losses in oncocytic or Hürthle cell thyroid carcinoma (HCC). This comprehensive analysis further unravels the unique features of HCC, either minimal or widely invasive in character and confirms previous work published on mtDNA mutations as well as the widespread loss of entire chromosomes (Bonora, et al. 2006; Corver, et al. 2012; Corver, et al. 2014; Gasparre, et al. 2007).