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Macrophage multinucleated giant cells: hallmarks of the aging ovary.

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Inflammaging is a state of chronic, low grade inflammation associated with biological aging which contributes to age-related diseases. Recently, an age-associated increase in inflammation has been documented in the mammalian… Click to show full abstract

Inflammaging is a state of chronic, low grade inflammation associated with biological aging which contributes to age-related diseases. Recently, an age-associated increase in inflammation has been documented in the mammalian ovary, which is accompanied by a shift in the immune cell profile. In this Point of View article, we consider a unique population of macrophage-derived multinucleated giant cells, found in all reproductively old mouse ovaries, as potential markers or functional drivers of inflammation in ovarian aging.

Keywords: hallmarks aging; cells hallmarks; giant cells; macrophage multinucleated; multinucleated giant

Journal Title: Reproduction
Year Published: 2020

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