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BACKGROUND: Hypoxic Ischemic encephalopathy (HIE) represents a major cause of brain damage in the neonatal population. Hypoxic ischemia stress triggers neuronal and glial injury leading to necrosis secondary to cellular… Click to show full abstract
BACKGROUND: Hypoxic Ischemic encephalopathy (HIE) represents a major cause of brain damage in the neonatal population. Hypoxic ischemia stress triggers neuronal and glial injury leading to necrosis secondary to cellular edema, lysis, and the resulting apoptosis in delayed cellular injury. Therapeutic hypothermia, the current standard of care, has been shown to be neuroprotective. Human adipose derived stem cells (hASCs) have shown to be a promising candidate for cell therapy for HIE. Apart from their anti-inflammatory activity through down regulation of cytokines, they secrete …
Journal Title: Pediatrics
Year Published: 2018
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