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Our current understanding of neonatal adrenal function is incomplete. Relationship between basal cortisol levels and various neonatal outcomes are inconclusive. However, direct precursor-to-product ratio can provide useful information about the… Click to show full abstract
Our current understanding of neonatal adrenal function is incomplete. Relationship between basal cortisol levels and various neonatal outcomes are inconclusive. However, direct precursor-to-product ratio can provide useful information about the network of pathways in cortisol biosynthesis. Objective: For this reason, we conducted a prospective study to assess adrenal steroid profile at birth. We studied the levels of 7 precursors and products of adrenal steroids in the cortisol biosynthesis / degradation pathway using liquid chromatography-tandem mass spectrometry …
Journal Title: Pediatrics
Year Published: 2018
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