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Adverse Early Life Environment Restricts Growth and Increases Hepatic Lipid Content

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Background: Children exposed to adverse early life environment (AELE) carry increased risk of growth restriction and metabolic disease, including non-alcoholic fatty liver disease (NAFLD). NAFLD occurs in animal models of… Click to show full abstract

Background: Children exposed to adverse early life environment (AELE) carry increased risk of growth restriction and metabolic disease, including non-alcoholic fatty liver disease (NAFLD). NAFLD occurs in animal models of maternal Western diet. Animal models of perinatal stress demonstrate disordered maternal behaviors and psychological sequelae in offspring but have not evaluated risk of hepatic disease. Our group combined the exposures of maternal Western diet and perinatal stress in a …

Keywords: life environment; growth; adverse early; early life

Journal Title: Pediatrics
Year Published: 2018

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