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Molecular Allergy Diagnostics Refine Characterization of Children Sensitized to Dog Dander

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U Kack, A Asarnoj, H Gronlund. J Allergy Clin Immunol. 2018;142(4):1113–1120.e9 To analyze patterns of immunoglobulin E (IgE) reactivity to dog allergen components in sensitized children and investigate the association… Click to show full abstract

U Kack, A Asarnoj, H Gronlund. J Allergy Clin Immunol. 2018;142(4):1113–1120.e9 To analyze patterns of immunoglobulin E (IgE) reactivity to dog allergen components in sensitized children and investigate the association between those patterns and clinical symptoms by nasal provocation tests (NPT). Children 10 to 18 years ( n = 60) with known sensitization to dog identified by a skin prick test wheal >3 mm or serum-specific IgE >10 kU/L were included. NPTs were performed with a commercial dog extract by using a standardized protocol. The extract was analyzed by radioallergosorbent test inhibition and contained all 6 dog allergens (Can f 1, 2, 3, 4, 5, and 6) used in subsequent analyses. The allergens were present in a wide range of concentrations. Serum-specific IgE levels to dog extract and each of the allergenic components were measured. All but 2 children had allergic rhinitis or conjunctivitis, and 41 out of 60 …

Keywords: allergy diagnostics; diagnostics refine; characterization children; refine characterization; molecular allergy; dog

Journal Title: Pediatrics
Year Published: 2019

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