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Specific IgG4 Antibodies to Cow’s Milk Proteins in Pediatric Patients With Eosinophilic Esophagitis

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AJ Schuyler, JM Wilson, A Tripathi. J Allergy Clin Immunol. 2018;142(1):139–148.e12 Although food protein causes eosinophilic esophagitis (EoE), the mechanism is not clear and appears not to be immunoglobulin E… Click to show full abstract

AJ Schuyler, JM Wilson, A Tripathi. J Allergy Clin Immunol. 2018;142(1):139–148.e12 Although food protein causes eosinophilic esophagitis (EoE), the mechanism is not clear and appears not to be immunoglobulin E (IgE)–mediated. Cow’s milk (CM) is among the most common causal foods in patients with EoE. Specific immunoglobulin G4 (sIgG4) antibodies to food extracts, including CM, have been found in sera and esophageal biopsies of adults with EoE. Is this true in children with EoE? This study included data from 71 pediatric patients with EoE and 210 pediatric control …

Keywords: igg4 antibodies; specific igg4; eosinophilic esophagitis; cow milk; pediatric patients

Journal Title: Pediatrics
Year Published: 2019

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