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The effects of fluid composition and shear conditions on bacterial adhesion to an antifouling peptide-coated surface

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Biofilms can damage implants and are difficult to treat. Here, we assessed the performance of a tripeptide that self-assembles into an antifouling coating over a broad range of shear conditions… Click to show full abstract

Biofilms can damage implants and are difficult to treat. Here, we assessed the performance of a tripeptide that self-assembles into an antifouling coating over a broad range of shear conditions that are relevant to biomedical applications. Adhesion assays were performed using a parallel plate flow chamber. The results show that the coating can reduce Escherichia coli adhesion up to 70% when compared with glass. At a shear rate of 15/s, typical for urinary catheters, the coating reduced the adhesion by more than 50%. These findings suggest critical features that should be considered when developing surfaces for biomedical purposes.

Keywords: conditions bacterial; adhesion; effects fluid; composition shear; fluid composition; shear conditions

Journal Title: MRS Communications
Year Published: 2018

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