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Efficacy of photodynamic therapy using UVB radiation-emitting novel phosphor material for non-surgical treatment of psoriasis

Ultraviolet (UV) light is the key to treat various skin conditions effectively. Commercial UV lamps emit a broad spectrum (width > 100 nm) and are widely used to treat skin diseases. Psoriasis is… Click to show full abstract

Ultraviolet (UV) light is the key to treat various skin conditions effectively. Commercial UV lamps emit a broad spectrum (width > 100 nm) and are widely used to treat skin diseases. Psoriasis is a non-contagious long-term skin infection that affects many people worldwide. Only a small part of the UV light spectrum is required for skin rejuvenation, which corresponds to action spectrum of psoriasis. However, the use of broadband emitting commercial UV light leads to side effects such as skin tanning, erythema, etc. To avoid this issue, a series of UV emitting Ca_2MgSi_2O_7:Gd^3+ phosphors that have a specific narrow wavelength range were prepared for the first time with promising results in the field of dermatology. The optimized Ca_2-xMgSi_2O_7:xGd^3+ phosphor had an intensity comparable to commercial LaPO_4:Ce^3+ phosphor (UVB-315), making the developed phosphor a promising option for the effective treatment of psoriasis in fewer lesions with minimal risk of erythema. Graphical abstract

Keywords: treatment psoriasis; phosphor; efficacy photodynamic; photodynamic therapy; psoriasis

Journal Title: Journal of Materials Research
Year Published: 2023

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