LAUSR

The purpose of this study was to study the local and serum levels of cytokines involved in the regulation of inflammation in patients with chronic endometritis in combination with endometrial hyperplastic processes.On admission to the hospital, all patients underwent hysteroscopy with separate diagnostic curettage and subsequent histological examination of scrapings of the mucous membrane of the uterus and cervical canal. Indications for their implementation were abnormal uterine bleeding, as well as suspicion of endometrial pathology according to ultrasound scanning. Based on the histological examination of the endometrial tissue, all patients were divided into two groups: Group I included 45 women with CE in combination with PEG without atypia; Group II - 38 patients with morphologically verified CEE in combination with AEG without atypia. Determination of the concentration of IL-1β, IL-2, IL-6, γ-INF, TNF-α in biological fluids (aspirate from the uterus; serum) was carried out by the method of enzyme-linked immunosorbent assay.In the course of this study, it was established that in the overwhelming majority of cases the cause of hospitalization of patients in both groups (91.1% and 89.6%, respectively) was abnormal uterine bleeding. Oligomenorrhea alternated with intermenstrual bleeding (66.7% and 71.2%, respectively) dominated in the structure of menstrual cycle disorders in the examined patients, while in 11 (24.4%) patients of group I and 7 (18.4% ) patients of the II group were noted heavy menstrual bleeding. In general, the analysis of our data on the concentration of cytokines in the aspirate from the uterus, and in the serum, indicates a continuing inflammatory process at the time of the survey. In this process is not only local, but also has signs of a systemic inflammatory response. Data on the level of cytokines in the aspirate from the uterus of patients with CE in combination with PGE or CGE without atypia indicate the presence of a local inflammatory process, which is characterized by a statistically significant increase in the concentration of IL-1β, IL-2, IL-6, TNF-α and γ -IFN. At the same time, a higher level of IL-1β and γ-IFN in patients of group II, probably indicates the influence of the degree of morphological changes in the endometrium on the level of local production of cytokines.Thus, the data obtained indicate that immune changes in chronic endometritis in combination with non-atypical hyperplastic processes of the endometrium occur mainly at the local level. In this regard, the determination of the concentration of cytokines in the aspirate from the uterus is prognostically significant for the diagnosis and monitoring of the effectiveness of therapy in this cohort of patients.