LAUSR

1Hospital de Clínicas de Porto Alegre (HCPA), Porto Alegre RS, Brasil. Conflict of interest: There is no conflict of interest to declare. Correspondence: Juliana Ávila Duarte; R. Ramiro Barcelos, 2350; 90035-903 Porto Alegre RS, Brasil; E-mail: [email protected] Received 05 March 2017; Received in final form 21 November 2017; Accepted 27 November 2017. A magnetic resonance imaging (MRI) exam was performed in an 11-month-old female patient with West syndrome who had been treated with vigabatrin for five months (131.5 mg/kg/day). The MRI showed asymptomatic changes (Figures 1, 2 and 3). Vigabatrin-associated MRI abnormalities occur in 10–20% of treated infants1,2. Animal studies have associated the use of vigabatrin with histopathologic abnormalities showing microvacuolization of glial cells and intramyelinic edema3,4. Neurologists and neuroradiologists should be aware of, and recognize these changes, as they are mostly transient and may be symptomatic or not. Asymptomatic abnormalities revealed on MRI appear to be dose dependent, according to recent studies5.