LAUSR

A 68-year-old woman presented with a four-year history of progressive difficulty performing daily activities like dressing, and sometimes colliding with objects when walking. An ophthalmology consultant excluded primary visual changes. Evaluation revealed apperceptive visual agnosia, simultanagnosia, optic ataxia, oculomotor, dressing and constructive apraxia. Other cognitive domains were relatively spared. Brain [18F]FDG-PET-CT showed bilateral temporoparietal hypometabolism with occipital cortex extension (Figure), compatible with the hypothesis of posterior cortical atrophy1,2, a neurodegenerative syndrome with an early and progressive decline in visuospatial and visuoperceptual skills, attributable to Alzheimer’s disease pathology in most patients3, that could be assessed by cerebrospinal fluid biomarkers, which were not available in this case.