LAUSR

OBJECTIVES To analyze the temporal trend of mortality from sickle cell anemia in Brazil, by region, in the period 1997-2017. METHODS epidemiological study, with an ecological design, with a temporal trend, carried out with data from the Mortality Information System. For descriptive analysis, absolute and relative frequencies were used. In the correlation analysis, the ANOVA test was used, followed by Tukey's post-test. The temporal trend was obtained using the cubic polynomial regression test. RESULTS 6,813 deaths from sickle cell anemia were registered. Brown individuals (50.87%) were more frequent, with a predominance of males (50.4%), aged between 25 and 34 years and a higher incidence of deaths in the Midwest (0.25/100 thousand inhabitants). The time curve showed an increasing trend of deaths in the country between 1997 and 2015 (R2 = 0.98). CONCLUSIONS sickle cell anemia showed increasing mortality in the 21 years analyzed and alerts health professionals and managers.