LAUSR

A 30-year-old man with a diagnosis of AIDS discontinued antiretro viral therapy one year prior to presentation for a headache, fever and weight loss evaluation. Chest computed tomography revealed excavated and septate lobulated formation in the left lower lobe (Figure 1A-B), and bronchoscopy revealed an infiltrative lesion in the left lower lobe bronchus (superior segment)(Figure 1C). The bronchial biopsy specimens showed many smallsized non-budding yeast-like structures, with periodic acid-Schiff staining positivity, compatible with Cryptococcus neoformans. Cryptococcus neoformans was also cultured from both blood and cerebrospinal fluid. The patient was treated with intravenous liposomal amphotericin B and fluconazole and underwent cerebrospinal fluid drainage. He followed an uncomplicated disease course.