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Bartholin’s gland adenoma in a Saanen goat

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EnglishTumors affecting Bartholin’s gland are considered rare in human medicine; there are few reports in the veterinary literature, with descriptions occurring only in cows. This article described the clinical and… Click to show full abstract

EnglishTumors affecting Bartholin’s gland are considered rare in human medicine; there are few reports in the veterinary literature, with descriptions occurring only in cows. This article described the clinical and pathological findings associated with Bartholin’s gland adenoma in a goat. Clinically, a 7-year-old pregnant Saanen goat presented bilateral enlargement of the vulva that did not regress spontaneously after parturition. Grossly, these vulvar masses were multilobulated, contained cystic areas from which oozed a whitish fluid. Histopathology revealed an adenoma characterized by the proliferation of irregularly shaped neoplastic epithelial cells that formed tubular to glandular-like structures. These neoplastic cells demonstrated moderate anisokaryosis and evident nucleoli. The intratumoral proliferation index (PI) was estimated by immunoreactivity with the protein ki-67. Further, the glandular-like structures produced a Periodic Acid-Schiff positive secretion. A diagnosis of Bartholin’s gland adenoma was established due to the anatomic location of the neoplastic growths, the histopathological features, and the PI of the tumor. Key words: Histopathology; ki-67 protein; adenoma; major vestibular glands portuguesTumores que afetam a glândula de Bartholin sao considerados raros em humanos e ha poucos relatos na medicina veterinaria, sendo descrito somente em vacas. Este artigo descreve os achados clinicos e patologicos associados ao adenoma na glândula de Bartholin em uma cabra. O animal da raca Saanen, com sete anos de idade e gestante apresentava aumento de volume bilateral na regiao da vulva, que nao regrediu apos o parto. Macroscopicamente, a massa era multilobulada, com presenca de varios cistos preenchidos por uma secrecao esbranquicada. A histopatologia revelou um adenoma, caracterizado por proliferacao de celulas epiteliais de formato irregular que formavam estruturas tubulares semelhantes a glândulas. Estas celulas neoplasicas apresentavam anisocariose moderada e nucleolos evidentes. O indice de proliferacao celular intratumoral (PI) foi estimado por imunorreatividade a proteina ki-67. Alem disso, a secrecao produzida por essas estruturas do tipo glandular, foi positiva na coloracao do Acido Periodico-Schiff. O diagnostico de adenoma da glândula de Bartholin foi estabelecido pela localizacao anatomica dos tumores neoplasicos, caracteristicas histopatologicas e a PI do tumor. Palavras-chave: histopatologia; ki-67; adenoma; glândulas vestibulares maiores

Keywords: adenoma; gland adenoma; bartholin; histopathology; bartholin gland

Journal Title: Ciencia Rural
Year Published: 2017

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