LAUSR

Background: Differences between HA-AKI and CA-AKI are not well stablished Methods: Retrospective cohort. We included 877 patients hospitalized with COVID at two hospitals in Mexico. Primary outcome was all-cause mortality at 28 days compared between COVID with CA-AKI and HA-AKI. Secondary outcomes included the need for KRT, and risk factors associated with the development of CA-AKI and HA-AKI. Results: A total 33.7% developed AKI. CA-AKI occurred in 59.9% and HA-AKI occurred in 40.1%. Patients with CA-AKI had more comorbidities than those with HAAKI. Patients' survival with CA-AKI it was 75.4%, and with HA-AKI 69.6%. Age > 60 years (OR 1.12), COVID severity (OR 1.09), mechanical ventilator (OR 1.67), and HAAKI 3 (OR 1.16) increase mortality. The presence of CKD (OR 1.48), serum lymphocytes < 1000 μL (OR 1.03), the need for mechanical ventilator (OR 1.06), and CA-AKI stage 3 (OR 1.37) were the only variables associated with a KRT start. Conclusions: We found that COVID complicated by CA-AKI have more comorbidities and worse biochemical parameters than HA-AKI patients, but despite these differences, their probability of dying is similar.