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Ischemia reperfusion injury (IRI) is the most common cause of in-hospital acute kidney injury and is associated with increased morbidity and mortality. IRI is associated with an early phase of… Click to show full abstract
Ischemia reperfusion injury (IRI) is the most common cause of in-hospital acute kidney injury and is associated with increased morbidity and mortality. IRI is associated with an early phase of inflammation primarily regulated by the canonical NFκB signalling pathway. Despite recent advances in our understanding of the pathogenesis of IRI, few therapeutic strategies have emerged. The purpose of this manuscript is to review interventions targeting NFκB following IRI. (Pubmed: NF kappaB, inhibition, ischemia reperfusion, kidney. Filter: 5 years).
Journal Title: Journal of the American Society of Nephrology : JASN
Year Published: 2021
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