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Management of immediate hypersensitivity reaction to glatiramer acetate

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Glatiramer acetate (GA; Copaxone®), a mixture of four synthetic polypeptides, is used in the form of subcutaneous injection (20 mg/day) for the treatment of multiple sclerosis (MS). Only few systemic… Click to show full abstract

Glatiramer acetate (GA; Copaxone®), a mixture of four synthetic polypeptides, is used in the form of subcutaneous injection (20 mg/day) for the treatment of multiple sclerosis (MS). Only few systemic reactions suggestive of anaphylaxis have been so far reported [1-10]. Anaphylaxis is estimated to develop in less than 0.1% of treated patients [8]. The most frequent systemic reaction is immediate post-injection systemic reaction (IPISR), which occurs at least once in 10-15% of patients [1]. IPISR [...]

Keywords: management immediate; glatiramer acetate; reaction; immediate hypersensitivity

Journal Title: European Journal of Dermatology
Year Published: 2017

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