Glatiramer acetate (GA; Copaxone®), a mixture of four synthetic polypeptides, is used in the form of subcutaneous injection (20 mg/day) for the treatment of multiple sclerosis (MS). Only few systemic… Click to show full abstract
Glatiramer acetate (GA; Copaxone®), a mixture of four synthetic polypeptides, is used in the form of subcutaneous injection (20 mg/day) for the treatment of multiple sclerosis (MS). Only few systemic reactions suggestive of anaphylaxis have been so far reported [1-10]. Anaphylaxis is estimated to develop in less than 0.1% of treated patients [8]. The most frequent systemic reaction is immediate post-injection systemic reaction (IPISR), which occurs at least once in 10-15% of patients [1]. IPISR [...]
               
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