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A novel WRN mutation identified in a patient with Werner syndrome and acute generalized exanthematous pustulosis

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553 including penicillin. Several studies have reported penicillin resistance rates from 12 to 27% [1, 7]. In our study, eight patients (34.8%) showed resistance to some antibiotics, and penicillin was… Click to show full abstract

553 including penicillin. Several studies have reported penicillin resistance rates from 12 to 27% [1, 7]. In our study, eight patients (34.8%) showed resistance to some antibiotics, and penicillin was the antibiotic for which more resistance was observed. A case of methicillin-resistant bacteria was isolated, and this should be taken into account, especially in resistant cases. Other cases of methicillin resistance have been previously reported [8]. The clinical outcome of SSTIs in our series was favourable and no complications were observed during or after treatment, even in patients with abscesses. In summary, it is important to consider that S. lugdunensis, previously regarded as a commensal bacterium, may have a pathogenic role in SSTIs, and especially HS. S. lugdunensis bears resistance to multiple antibiotics and this should be investigated, however, the prognosis of skin infections is usually good with specific antibiotic treatment.

Keywords: wrn mutation; novel wrn; resistance; identified patient; patient werner; mutation identified

Journal Title: European Journal of Dermatology
Year Published: 2018

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