LAUSR

EJD, vol. 29, n◦ 6, November-December 2019 Patients 1 and 3 reported here), though primary or secondary generalization (as found in Patient 3) can be observed [4]. In Patient 2, radiotherapy was probably not a triggering factor as the eruption was immediately generalized and delayed three years after radiation, however, we can hypothesize that this was an exacerbating factor for the unusually severe oral mucosal involvement as the latter concerns only 20% of BP cases and is generally mild [5]. A review of the literature revealed no association between BP and malignancy [6]. The association between malignancy-associated MMP and anti-laminin-332 antibodies remains controversial [7]; no circulating antibodies were detected in Patient 3. Though we cannot exclude a link between breast carcinoma and MMP in this patient, lesions were initially predominantly located on the irradiated area. Spontaneous clinical outcome of radiotherapy-induced autoimmune blistering diseases is not assessable since patients usually receive standard treatments.