LAUSR

Glomuvenous malformations (GVM), previously known as glomangiomas, are an uncommon subset of venous malformation (VM), characterized by distinct histopathology, clinical presentation and association with loss-of-function mutations in the glomulin gene (GLMN) [1]. Classically, they occur as painful, bluish solitary papules, widely scattered nodules or segmental plaques that are frequently hyperkeratotic and may assume a cobblestone-like appearance. In contrast to classic VM, GVM are often present at birth, and increase in size slowly during childhood. They rarely affect the mucosa, viscera or joints and a positive family history is present in approximately two thirds of the patients [2]. While skin biopsy is not always required for diagnosis, histopathology of GVM demonstrates venous-like channels surrounded by glomus cells, which stain positive for vimentin and -smooth muscle actin and negative for desmin [1, 3]. Treatment options in selected cases include sclerotherapy, laser therapy and surgical excision [1].