LAUSR

espanolIntroduccion: existen datos controvertidos sobre la asociacion entre la enfermedad celiaca (ECe) y la enfermedad inflamatoria intestinal (EII). Objetivo: estudiar la prevalencia de la ECe en pacientes recien diagnosticados de EII. Metodos: estudio observacional retrospectivo con cribado de ECe en pacientes con diagnostico reciente de EII mediante la determinacion de anticuerpos antitransglutaminasa tisular (AATGt) y biopsia duodenal endoscopica. Ninguno de los pacientes habia recibido corticoides, inmunosupresores o farmacos biologicos en los tres meses previos a la gastroscopia. En caso de presencia de Marsh 1, se excluyeron otras causas. Se diagnostico ECe en pacientes con AATGt positivos, biopsia duodenal compatible y buena respuesta a dieta sin gluten. Resultados: se realizo cribado de ECe en 163 pacientes. De ellos, seis tuvieron AATGt positivos (3,7% del total) y cuatro fueron diagnosticados de ECe (tres con colitis ulcerosa y uno con enfermedad de Crohn). Todos los pacientes con ECe y EII tenian niveles de IgA normales, AATGt positivos y marcadores geneticos de ECe. Conclusiones: la prevalencia de ECe en nuestros pacientes con EII es mayor que la referida en otras series publicadas en la literatura de pacientes con EII. La combinacion de AATGt y estudio genetico de ECe en pacientes con EII permite el cribado de ECe en esta poblacion. EnglishIntroduction: controversial data have been reported on the potential association between celiac disease (CeD) and inflammatory bowel disease (IBD). Objective: to study the prevalence of CeD in patients newly diagnosed cases with IBD. Methods: an observational, retrospective study was performed in patients with newly diagnosed IBD who were screened for CeD by anti-tissue transglutaminase antibodies (anti-tTG) measurements and an endoscopic duodenal biopsy. No patients had received corticosteroids, immunosuppressants or biologic drugs within the three months prior to gastroscopy. In the presence of Marsh 1, other causes were ruled out. CeD was diagnosed in patients positive for anti-tTG, compatible duodenal biopsy findings and a good response to a gluten-free diet. Results: a total of 163 patients were screened for CeD. Of these, six (3.7%) were positive for anti-tTG and four were diagnosed with CeD (three had ulcerative colitis, one had Crohn’s disease). All patients with both CeD and IBD had normal IgA levels, positive anti-tTG and CeD genetic markers. Conclusions: the prevalence of CeD in our patients with IBD was higher than that reported in the literature for other series of patients with IBD. A combination of anti-tTG testing and CeD genetics may screen patients for CeD in this population of patients with IBD.