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Regulation of Protein Degradation and Homeostasis by the Cytokine- Inducible Deubiquitinating Enzymes

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Ubiquitin-proteasome system (UPS) is the major signaling pathway responsible for regulating protein turnover in cells. Deubiquitinating enzymes (DUBs) have an important role in this signaling pathway by eliminating ubiquitins from… Click to show full abstract

Ubiquitin-proteasome system (UPS) is the major signaling pathway responsible for regulating protein turnover in cells. Deubiquitinating enzymes (DUBs) have an important role in this signaling pathway by eliminating ubiquitins from substrates and inhibiting proteasomal degradation to maintain cellular homeostasis.

Keywords: degradation; degradation homeostasis; regulation protein; protein degradation; deubiquitinating enzymes

Journal Title: Journal for ImmunoTherapy of Cancer
Year Published: 2018

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