Lithium is an agent with established neuroprotective qualities and considerable epidemiological evidence supporting its use as a dementia prophylactic. Yet it has failed to enter regular clinical use for this… Click to show full abstract
Lithium is an agent with established neuroprotective qualities and considerable epidemiological evidence supporting its use as a dementia prophylactic. Yet it has failed to enter regular clinical use for this purpose-not for lack of evidence, but rather arguably for saturation of poor-quality evidence and aborted peripheral clinical trials. This narrative review discusses the story of lithium’s almost rise to fame, and discusses future opportunities.
               
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