LAUSR

Stress and stressor-related disorders are the global illnesses. The immune system isthought to be strengthened by apoptogenic substances due to their ability of restoring normal body functions, which were imbalanced due to the presence of stressful conditions. The aim of study is to evaluate anti stress potential in ethanolic extract of Olea europaea (O. europaea) leaves on swimming endurance test in mice, cold and immobilization stress in rats. The effect was assessed by swimming survival time and estimation of biochemical parameter, weight of gland, organs, blood count in cold and immobilization stress at a dose 400 and 600 mg/kg per oral(p.o). The results demonstrated on comparison with stress models with O. europaea leaf extract and Gerifort Syrup showing significant increase (p It was experimentally compared to control and gerifort group. Thus, obtained results revealed that the leaf extract of O. europaea have potential Anti-stress activity due to the existence of phenolic compounds, especially secoiridoids and iridoids and antioxidant molecules, such as oleuropein, hydroxytyrosol, tyrosol, caffeic acid, and ligstroside proving its significant anti stress activity. Keywords: Swimming, Cold stress, Olea europaea, WBC, BUN, TG.