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Expression of EZH2 in uveal melanomas patients and associations with prognosis

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Purpose To analyze the prognostic value and potential target for therapeutic intervention of enhancer of zeste homologue 2 (EZH2) in uveal melanomas (UM) patients. Method We analyzed EZH2 expression in… Click to show full abstract

Purpose To analyze the prognostic value and potential target for therapeutic intervention of enhancer of zeste homologue 2 (EZH2) in uveal melanomas (UM) patients. Method We analyzed EZH2 expression in 89 primary UM patients by immuno- histochemistry to observe the clinicopathological and prognostic value of EZH2. Results The high levels of mitoses count and Ki67 labeling index had significant correlation with overexpression EZH2 (R = 0.408, P Conclusion Our critical finding is that overexpression EZH2 in UM can be served as predictive marker and is associated with adverse clinical outcomes. Further observation of EZH2 as a potential therapeutic target in UM is necessary.

Keywords: ezh2 uveal; melanomas patients; uveal melanomas; ezh2; expression

Journal Title: Oncotarget
Year Published: 2017

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