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Internal translational initiation of the mRNA encoding the Arf tumor suppressor yields an N-terminally truncated small Arf protein (smArf) that lacks amino acid residues required for Mdm2 binding and p53… Click to show full abstract
Internal translational initiation of the mRNA encoding the Arf tumor suppressor yields an N-terminally truncated small Arf protein (smArf) that lacks amino acid residues required for Mdm2 binding and p53 activation. Here, we report that female, but not male, mice engineered to produce only smArf in lieu of the full-length Arf protein retain residual, sexually dimorphic tumor suppressive activity.
Keywords:
arf;
dimorphic tumor;
tumor suppression;
sexually dimorphic;
suppression small;
tumor
Journal Title: Oncotarget
Year Published: 2019
Link to full text (if available)
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Journal Title: Oncotarget
Year Published: 2019
Link to full text (if available)
Share on Social Media: Sign Up to like & get
recommendations!