LAUSR

INTRODUCTION The glomerular filtration rate (GFR) is an important indicator of renal function, and its precise measurement is essential for guiding clinical management. However, studies evaluating the performance of GFR-estimation equations in patients with end-stage renal disease (ESRD) not on dialysis remain scarce. OBJECTIVE Our work sought to identify a relative accurate equation for estimating the residual renal function in patients with ESRD not on dialysis. PATIENTS AND METHODS We used the revised Gates method as the gold standard to measure the GFR of 101 patients with ESRD not on dialysis. 23 equations (CKD-EPIScr, MDRDII, FASScr, EKFC, Lund-Malmö Revised, Mayo, XiangYa, XiangYa-s, Vilar, Shafiβ2M, CKD-EPISCysC, FASSCysC, CAPA, Hoek, Yang, CKD-EPIScr-SCysC, FASScr-SCysC, Adachi, ShafiβTP, ShafiβTP-β2M, Wong, CKD-EPI_3M and CKD-EPI_4M) were used to estimate the patients' glomerular filtration rate. RESULTS The GFR measured by the dual plasma sampling method (dGFR) and the revised Gates method (rGFR) agreed well. The median dGFR and rGFR were 13.1ml/min/1.73m2 and 10.7ml/min/1.73m2, respectively. Overall in the population, the Lund-Malmö Revised (LMR) equation showed the low bias (median: 0.6), high precision (IQR: 4.30) and the highest accuracy (P30: 65.3%). CONCLUSION Based on these criteria, we recommend to use the LMR equation, albeit with large deviations, in estimating GFR in patients with ESRD not on dialysis.