LAUSR

INTRODUCTION Precancerous conditions for esophageal (EA) and gastric adenocarcinoma (GA) are Barrett's esophagus (BE) and atrophic gastritis (AG), respectively. The surveillance of which is crucial in the detection of early lesions. OBJECTIVES The study aimed to assess whether one-time esophagogastroduodenoscopy (EGD) in searching for precancerous conditions would be effective in a low-to-moderate esophageal and gastric cancer risk population. PATIENTS AND METHODS 5984 individuals who underwent diagnostic EGD in 3 endoscopic centers from 03.2018 to 10.2019 were analyzed to assess the age of patients with precancerous conditions and cancers. Age distribution of patients with malignant gastric and esophageal tumors registered in the national cancer registry (KRN) from 2014 to 2017 was analyzed. RESULTS The risk of diagnosis of EA and GA raised in comparison with individuals at age <40 at age 60-64 (OR 12.1; 95%CI 1.5-98.6), gastric and esophageal dysplasia at age 55-59 (OR 3.6; 95%CI 1.3-9.7), and BE and AG at age 40-44 (OR 1.6; 95%CI 1.04-2.4). The number of procedures per one cancer that could be potentially avoided was 236, 235, 290, 360, 394, and 344 for age groups 40-44, 45-49, 50-54, 55-59, 60-64, and 65-69 respectively. The assessed ratio of potential benefits and harms was 47, 38, 31, 28, and 32 for age groups 40-49, 50-54, 55-59, 60-64, and 65-69 respectively. CONCLUSIONS The one-time EGD in searching for precancerous conditions could be potentially applicable in individuals between 40 and 69 years of age.