LAUSR

A 57-year-old female with a history of alcoholic cirrhosis presented with melena. Initial upper endoscopy performed at an outside facility revealed a possible ulcer in the second part of the duodenum (D2), treated with 3 hemoclips. The patient was transferred to our institution for further management. Repeat endoscopy revealed a large varix in D2 with active bleeding and adjacent prior hemoclips (Fig. 1A). She was referred for emergency transjugular intrahepatic portosystemic shunt (TIPS). Pre-procedural computed tomography angiography demonstrated large paraduodenal collaterals and duodenal varices (DV) corresponding to what was seen on endoscopy (Fig. 2). She underwent TIPS and coil embolization of the DV. She continued to experience bleeding, requiring upsizing of the TIPS. Further bleeding prompted endoscopic cyanoacrylate glue injection directly into the varix (Fig. 1B). After an initial response, the bleeding resumed and was only controlled after repeat coil embolization of residual paraduodenal collaterals feeding the DV. Unfortunately, she succumbed to sepsis and fungemia despite receiving appropriate antibiotics and antifungals. DV are a complication of portal hypertension and are considered ectopic varices. These are portosystemic collaterals in locations besides the gastroesophageal region and represent 2-5% of variceal bleeding. Seventeen percent of ectopic variceal bleeding is from DV [1]. The most common site for DV is the duodenal bulb, followed by D2 [2]. The mortality rate for acute bleeding is up to 40% [3]. Because of its rarity, there have been no randomized trials concerning the management of this condition. DV are challenging to treat and can be fatal.