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Ocrelizumab-induced inflammatory bowel disease-like illness characterized by esophagitis and colitis

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Ocrelizumab is an intravenous anti-CD20 monoclonal antibody, approved for use in primary progressive multiple sclerosis due to its selective depletion of B-lymphocytes. Herein we describe the case of a 56-year-old… Click to show full abstract

Ocrelizumab is an intravenous anti-CD20 monoclonal antibody, approved for use in primary progressive multiple sclerosis due to its selective depletion of B-lymphocytes. Herein we describe the case of a 56-year-old female who developed odynophagia and bloody diarrhea following treatment with ocrelizumab. This was characterized endoscopically by ulcerations in the esophagus and colon. The patient was treated with high-dose intravenous glucocorticoids with good clinical response.

Keywords: bowel disease; inflammatory bowel; like illness; disease like; ocrelizumab induced; induced inflammatory

Journal Title: Annals of Gastroenterology
Year Published: 2021

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