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Electrochemical degradation of valproic acid drug (VAc) was studied by direct and indirect electrochemical oxidation processes using platinum electrode. The effect of halide counteranions on oxidation of valproic acid and… Click to show full abstract
Electrochemical degradation of valproic acid drug (VAc) was studied by direct and indirect electrochemical oxidation processes using platinum electrode. The effect of halide counteranions on oxidation of valproic acid and its electrochemical mineralization in hydro-alcoholic solution was investigated. The electrochemical behavior of valproic acid was studied by cyclic voltammetry and spectrophotometrical assisted electrolysis in the presence of fluoride, chloride and bromide anions. Bromide electromediated was shown to be the most efficient degradation process. A plausible mineralization mechanism was proposed. In addition, thermal deactivation of valproic acid was studied by simultaneous thermogravimetry/differential scanning calorimetry (TG/DSC).
Journal Title: International Journal of Electrochemical Science
Year Published: 2021
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