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Cigarette smoke, and the mutagen agents it contains, is a universal conveyor of DNA alterations in the pulmonary airway cells, ultimately leading to cancer. In addition, the thousands xenobiotics and… Click to show full abstract
Cigarette smoke, and the mutagen agents it contains, is a universal conveyor of DNA alterations in the pulmonary airway cells, ultimately leading to cancer. In addition, the thousands xenobiotics and pro-oxidant agents contained in smoke participate in the pathophysiology of chronic obstructive pulmonary diseases (COPD) and emphysema by inducing cell death, chronic inflammation, and deregulated extracellular matrix degradation and remodeling.
Keywords:
smoke induced;
cigarette smoke;
deadly association;
autophagy deadly;
cigarette;
induced autophagy
Journal Title: Journal of thoracic disease
Year Published: 2017
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Journal Title: Journal of thoracic disease
Year Published: 2017
Link to full text (if available)
Share on Social Media: Sign Up to like & get
recommendations!