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The hallmarks of established cancers have been meticulously catalogued over decades, almost entirely through the study of advanced disease (1). By contrast, the molecular features of early pre-neoplastic lesions including… Click to show full abstract
The hallmarks of established cancers have been meticulously catalogued over decades, almost entirely through the study of advanced disease (1). By contrast, the molecular features of early pre-neoplastic lesions including the occult alterations that presage progression to invasive and metastatic cancer, remain elusive (2). A better understanding of the biology of nascent cancers and the complex genetic and epigenetic evolutionary processes that drives them towards lethal disease, represents an important step towards more effective early intervention strategies.
Journal Title: Journal of thoracic disease
Year Published: 2019
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