In 1894, Halsted defined that a primary tumour spread first through lymphatics vessels to lymph nodes and then to distant organs. Hellman argued that cancer, even at the time of… Click to show full abstract
In 1894, Halsted defined that a primary tumour spread first through lymphatics vessels to lymph nodes and then to distant organs. Hellman argued that cancer, even at the time of diagnosis, is a biologic variety from a local to systemic illness with several transitional states. Subsequently, in 1995, Hellman and Weichselbaum first suggested the oligometastatic theory, where the number of metastases should imitate the biologic behaviour of a tumour, determining the chance for potential therapeutic interventions (1). In the eighth edition of the TNM classification, intrathoracic metastatic disease recollects the M1a classification.
               
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