LAUSR

Melanoma is the most lethal form of skin cancer. Based on the anatomical site, it can be classified as cutaneous (with or without chronic sun-induced damage), acral, or mucosal (1). Cutaneous melanoma is the predominant subtype in Caucasian populations (2). However, acral and mucosal melanomas are more common in African and Asian populations (3). Among white people, acral melanomas account for approximately 10% of all cases of melanoma, but in Asians, they account for 50–70% (4,5). The treatment for melanoma include surgery, chemotherapy, radiation therapy, targeted therapy and immunotherapy. Earlystage melanomas often be treated with surgery alone, but more advanced cancers usually require other treatments, sometimes it will use more than one type of treatment. There have been some genomic profiling studies of melanoma in recent decades. The Cancer Genome Atlas (TCGA) described the landscape of genomic alterations Original Article