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Construction of a novel ceRNA network and identification of lncRNA ADAMTS9-AS2 and PVT1 as hub regulators of miRNA and coding gene expression in gastric cancer

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Gastric cancer (GC), a malignant disease with the highest incidence among digestive tract, is the second leading cause of cancer-related mortality worldwide (1). GC prognosis depends primarily on tumour stage.… Click to show full abstract

Gastric cancer (GC), a malignant disease with the highest incidence among digestive tract, is the second leading cause of cancer-related mortality worldwide (1). GC prognosis depends primarily on tumour stage. Patients with GC usually present with advanced stages of the disease at initial diagnosis, and the 5-year survival rate of these patients is significantly lower than that of patients with early diagnosis (2). Early detection and diagnosis are key to reducing GCrelated mortality, and thus, new clinical biomarkers for early tumour diagnosis, monitoring treatment response, and predicting prognosis are urgently needed. Original Article

Keywords: diagnosis; gastric cancer; novel cerna; cerna network; construction novel; cancer

Journal Title: Translational cancer research
Year Published: 2021

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