LAUSR

Gastric cancer (GC) is a type of highly malignant lesion of the digestive tract that usually occurs in middle-aged and elderly individuals. The latest statistics show that GC ranks fourth out of all malignant tumors in incidence and third in mortality rates (1). Over the past 50 years, clinicians have been using traditional treatments, such as surgery, radiation therapy, chemotherapy, and combination therapy, as the main treatments for cancer, but with little success. Therefore, the improvement of GC prognosis and the development of new anticancer drugs is imperative. The JAK2/STAT3 signaling pathway participates in physiological and pathological reactions, cell proliferation, differentiation, apoptosis, and other processes (2,3). An abnormally sustained activation of STAT3 was identified (4-6) in breast, lung, head and neck cancer, among others. Previous studies have shown that the JAK2/STAT3 pathway affects cancer development by influencing Original Article