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A mechanism for the tissue specificity in BAP1 cancer syndrome

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Cancer predisposition syndromes are caused by inherited mutations in tumor suppressor genes. Remarkably, despite the presence of the faulty tumor suppressor gene in virtually every cell in the body, individuals… Click to show full abstract

Cancer predisposition syndromes are caused by inherited mutations in tumor suppressor genes. Remarkably, despite the presence of the faulty tumor suppressor gene in virtually every cell in the body, individuals with a cancer predisposition syndrome develop tumors in specific organs but not others.

Keywords: bap1 cancer; mechanism tissue; tissue specificity; specificity bap1; cancer syndrome; cancer

Journal Title: Translational cancer research
Year Published: 2019

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