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KRAS mutant NSCLC cells require active nuclear export of Iκβα (also known as NFKBIA), a negative regulatory protein of NF-κB signaling, for maintaining survival signaling (1-3). Nuclear export receptor XPO1… Click to show full abstract
KRAS mutant NSCLC cells require active nuclear export of Iκβα (also known as NFKBIA), a negative regulatory protein of NF-κB signaling, for maintaining survival signaling (1-3). Nuclear export receptor XPO1 correlates with KRAS mutation status.
Keywords:
inhibition mek;
mutant nsclc;
canonical kras;
kras mutant;
mek canonical;
kras pathway
Journal Title: Translational lung cancer research
Year Published: 2018
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Journal Title: Translational lung cancer research
Year Published: 2018
Link to full text (if available)
Share on Social Media: Sign Up to like & get
recommendations!