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Immunotherapy is transforming the care of cancer. In the past five years, checkpoint blockade agents targeting the PD-1/PD-L1 checkpoint (e.g., nivolumab, pembrolizumab) have garnered FDA approvals in diverse indications including… Click to show full abstract
Immunotherapy is transforming the care of cancer. In the past five years, checkpoint blockade agents targeting the PD-1/PD-L1 checkpoint (e.g., nivolumab, pembrolizumab) have garnered FDA approvals in diverse indications including melanoma, non-small cell lung cancer (NSCLC), renal cell carcinoma, and more (1-5). While these agents produce durable responses for some patients, the science of identifying responders remains inexact; further work is needed to identify biomarkers which better predict patient response than current clinical practice.
Journal Title: Translational lung cancer research
Year Published: 2018
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