LAUSR

Objective. To evaluate the impact of rotavirus (RV) vaccina­tion after 10 years of it´s universalization on morbidity and mortality from Acute Diarrheal Disease (ADD) in mexican children under five years of age. Materials and methods. Annual median numbers for ADD new cases, hospitalizations and deaths were compared between pre and post univer­salization periods; absolute and relative reductions were calculated, considering p <0.05 values as significant. Results. Mortality, hospitalizations and new cases from ADD in chil­dren under five decreased 52.6, 46, and 15.5% respectively, in the posuniversalization period. During rotavirus seasons, reduction in mortality, hospitalizations and new cases was 66.9, 64.7, and 28.7% respectively. Conclusions. As of the universal introduction of RV vaccination in Mexico, significant and sustained reductions are appreciated for mortality and hospitalizations from ADD, less so for incidence. A most prominent effect is observed during the winter season.