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Mannich-type addition of cyclic 1,3-diketones to N-acyliminium ions: Access to aza-sugars.

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A novel three-component strategy has been developed for the synthesis of iminosugars in good to excellent yields. This is the first report on the Mannich type addition of cyclic 1,3-diketones… Click to show full abstract

A novel three-component strategy has been developed for the synthesis of iminosugars in good to excellent yields. This is the first report on the Mannich type addition of cyclic 1,3-diketones to aza-acetal derived from hydroxy-γ-lactone and arylamine to produce a novel series of aza-sugars with high selectivity.

Keywords: aza sugars; type addition; mannich type; addition cyclic; cyclic diketones

Journal Title: Carbohydrate research
Year Published: 2023

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