LAUSR

1Dow Medical College, Dow University of Health Sciences, Karachi, Pakistan; 2Kabir Medical College, Gandhara University, Peshawar, Pakistan Dear editor Moudgal et al published an article in Clinical and Experimental Gastroenterology titled “Systemic Disease Associations with Disorders of Gut–Brain Interaction and Gastrointestinal Transit: A Review”. We want to express our gratitude to the authors for publishing such a thorough review study and would like to make some suggestions. The paper discussed a variety of multisystem illnesses and their pathophysiological links to disorders of gut brain interface (DGBI) and gastrointestinal motor dysfunction, presenting gastroenterologists with a foundation for differential diagnosis. Although the article mentioned most of the systemic disorders, we noticed the lack of the overlap of GI symptoms and autism spectrum disorder (ASD) core symptoms. Autism spectrum disorder (ASD) is a complex neurodevelopmental disorder which manifests as variable phenotypes with different subendo-phenotypes that may represent GI abnormalities. A meta-analysis carried out in 2014 by McElhanon et al, showed that children with ASD, unlike the comparison groups, expressed significantly more general GI symptoms: diarrhea, abdominal pain, and constipation. Recent studies have shown the shared pathogenic factors and pathophysiological mechanisms revealing the possible link between GI and ASD disturbances, including inflammation of intestine with or without autoimmunity, visceral hypersensitivity with functional abdominal pain and autonomic dysfunction with GI reflux and dysmotility. Absent or slow acquirement of bowel training secondary to trouble with sensory processing and motor problems may lead to altered GI motility and defecation physiology. Research carried out by Afzal et al concluded moderate-to-severe constipation in 36% of children with ASD compared to 9% in a control population. The diagnosis of GI disorders in patients with ASD can be very challenging due to the behavioral expressions, thus, doctors recommend using less invasive methods of investigation before hospitalization. In his research, Wasilewska et al concluded that GI disorders in children with ASD may vary greatly in their nature and localization. Due to the phenotypical representation as comorbidity of ASD and GI disorders, we suggest treating this situation as an “overlap syndrome”. Children with ASD who have GI disease and are experiencing unexplained anxiety, self-injury, sleep deprivation, aggression, and agitation will benefit from this concept. We have made significant progress in our studies of ASD; however, Correspondence: Syeda Lamiya Mir Dow Medical College, Dow University of Health Sciences, Karachi, Pakistan Email [email protected]