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Surrogacy in Antimicrobial Susceptibility Testing of Group A Streptococcus [Letter]

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1. The authors in this study have isolated and tested a total of 23 isolates of S. pyogenes against following antibiotics: erythromycin (15 μg), azithromycin (15 μg), tetracycline (), chloramphenicol… Click to show full abstract

1. The authors in this study have isolated and tested a total of 23 isolates of S. pyogenes against following antibiotics: erythromycin (15 μg), azithromycin (15 μg), tetracycline (), chloramphenicol (30 μg), clindamycin (2 μg), vancomycin (30 μg), ceftriaxone (30 μg), and penicillin (10 μg). However, CLSI guidelines states that penicillin is tested as a surrogate for cefazolin, cefepime, ceftaroline, cephradine, cephalothin, cefotaxime, ceftriaxone, ceftizoxime, imipenem, ertapenem, and meropenem for groups A, B, C, and G beta-hemolytic streptococci. Penicillin is also surrogate for cefaclor, cefdinir, cefprozil, ceftibuten, cefuroxime, and cefpodoxime for group A beta-hemolytic streptococci.

Keywords: surrogacy antimicrobial; group; susceptibility testing; testing group; antimicrobial susceptibility; group streptococcus

Journal Title: Infection and Drug Resistance
Year Published: 2023

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